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This and other evidence suggests that the principle ''use it or lose it" might apply to the ageing brain. Professor Shimamura studied a group of university professors who were still intellectually active, and compared their performance on neuropsychological tests with that of others of their age group, as well as with younger people. He found that on several tests of memory, the mentally active professors in their sixties and early seventies were superior to their contemporaries, and as good as the younger people.